![]() If persistent injection or infusion site reactions occur, discontinue Lyumjev and initiate therapy with an alternative insulin.BENTONVILLE, Ark., JWalmart announced the launch of the first-ever private brand analog insulin, which will revolutionize the access and affordability to diabetes care by offering customers a significant price savings without compromising quality. Monitor injection and infusion sites closely when initiating therapy with Lyumjev in pediatric patients. It is expected that Lyumjev-treated pediatric patients who receive continuous subcutaneous insulin infusion (CSII) are more likely to have infusion site-related adverse reactions than those who receive subcutaneous injections. Lyumjev-treated pediatric patients reported a higher incidence of subcutaneous injection site-related reactions compared to Lyumjev-treated adults. Particularly close monitoring may be required. Signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs. Some medications may alter glucose metabolism, insulin requirements, and the risk for hypoglycemia or hyperglycemia. Patients using subcutaneous insulin infusion pumps must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.Īdverse reactions associated with Lyumjev and Humalog include hypoglycemia, hypokalemia, allergic reactions, injection- or infusion-site reactions, lipodystrophy, localized cutaneous amyloidosis, pruritus, rash, weight gain, and peripheral edema. Pump or infusion set malfunctions and insulin degradation can lead to a rapid onset of hyperglycemia and ketoacidosis. Hyperglycemia and Ketoacidosis Due to Insulin Pump Device Malfunction: Observe patients for signs and symptoms of heart failure and consider discontinuation or dose reduction of the PPAR-gamma agonist. This may lead to or exacerbate heart failure. Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Lyumjev and Humalog. If hypersensitivity reactions occur, discontinue the use of Lyumjev or Humalog and treat per standard of care until signs and symptoms resolve.įluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Lyumjev and Humalog. Monitor potassium levels in patients at risk for hypokalemia (e.g., patients using potassium-lowering medications or medications sensitive to serum potassium concentrations). Insulins, including Lyumjev and Humalog, cause a shift in potassium from the extracellular to intracellular space possibly leading to hypokalemia, which, if untreated, may result in respiratory paralysis, ventricular arrhythmia, and death. Do not transfer Lyumjev U-200 from the Lyumjev KwikPen ® to a syringe and do not transfer Humalog U-200 from the Humalog KwikPen ® to a syringe as overdose and severe hypoglycemia can occur. ![]() Instruct patients to always check the insulin label before each injection to avoid medication errors. Monitor blood glucose and increase monitoring frequency with changes to insulin dosage, coadministered medications, meal pattern, or physical activity in patients with renal or hepatic impairment and in patients with hypoglycemia unawareness. Hypoglycemia is the most common adverse reaction of Lyumjev and Humalog. ![]() Severe hypoglycemia may be life threatening, may lead to unconsciousness, and can cause seizures or death. For patients with type 2 diabetes, dosage adjustments of concomitant antidiabetic products may be needed. Due to reports of hyperglycemia and hypoglycemia, advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor blood glucose. Use caution and close medical supervision when making any changes in insulin regimen and increase the frequency of blood glucose monitoring. Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen:Ĭhanges in insulin strength, manufacturer, type, injection site, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. Sharing poses a risk for transmission of blood-borne pathogens. Patients using Lyumjev or Humalog vials must never share needles or syringes with another person. Never Share a Lyumjev or Humalog Prefilled Pen, Cartridge, Syringe, or Humalog Reusable Pen Compatible with Lilly 3 mL Cartridges Between Patients, even if the needle is changed. Contraindications - Lyumjev and Humalog are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to these insulins or any of their excipients. ![]()
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